Studies on the Oxidation of N-Substituted-dibenz [b, f] azepines I. Oxidation with m-Chloroperbenzoic Acid

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概要

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• Oxidation of various N-substituted-dibenz [b, f] azepines with m-chloroperbenzoic acid (m-CPBA) was examined. Oxidation of N-acyldibenz [b, f] azepines (If-k) gave the 10,11-oxide (XVIIf-k). Oxidation of N-alkyldibenz [b, f] azepines (Ia-c) gave the diphenylamine (IIa-c) and 9-acridone (IIIa-c). Oxidation of N-methyldibenz [b, f]-azepine (Id) gave the N-oxide (IX) as a main product. In the case of oxidation of N-phenyldibenz [b, f] azepine (Ie), hydroxylation of the phenyl nucleus occurred to give N-(o-hydroxy) phenyldibenz [b, f] azepine (XII). In addition, further oxidation of XII proceeded to give diphenylamine (IIe). The rates of oxidation of N-substituted-dibenz [b, f] azepines (Ia-c) having an N-alkyl group were faster than those of If-k (having an N-acyl group).

• 社団法人日本薬学会の論文
• 1981-05-23

著者

• 広部 雅昭

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 宮田 直樹

  National Institute Of Hygienic Sciences University Of Tokyo

• 大田 富夫

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 宮田 直樹

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 大田 富夫

  Tokyo Research Laboratories Kowa Co. Ltd.

• 広部 雅昭

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 広部 雅昭

  東京大学薬学部:文部省

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