マスフラグメントグラフィーによるN^4-Behenoyl-1-β-D-arabinofuranosylcytosineの尿中代謝物Ara-U, Ara-Cの同時微量分析

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概要

• 論文の詳細を見る

• A method for the determination of Ara-C and Ara-U, the major metabolites of N^4-behenoyl-1-β-D-arabinofuranosylcytosine (BH-AC), was established by means of mass fragmentography. The acetylmethylated Ara-C and acetylated Ara-U were prepared and examined by gas chromatography-mass fragmentography (GC-MF). Each derivative was separated on 3% SE-30 column at 250℃. The contents of Ara-C and Ara-U were estimated from the calibration curve with papaverine as an internal standard. The urinary metabolites of BH-AC could be analyzed by this method without any extraction or separation procedure. This method is suitable for the selective analysis of Ara-C and Ara-U from the urinary metabolites of BH-AC.

• 社団法人日本薬学会の論文
• 1982-01-25

著者

• 渡辺 敬三

  東京大学薬学部

• 広部 雅昭

  東京大学薬学部

• 牧野 由紀子

  東京大学薬学部

• 松原 行雄

  東京大学薬学部

• 牧野 由紀子

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 広部 雅昭

  東京大学薬学部:文部省

• 牧野 由紀子

  Faculty Of Pharmaceutical Sciences University Of Tokyo

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