2-オキサゾロン骨格の脱離能を利用した試薬類
スポンサーリンク
概要
- 論文の詳細を見る
A 4, 5-unsubstituted 2-oxazolone moiety has proved of much synthetic potential as an excellent leaving group in carboxy-activating processes, in contrast with the 2-oxazolidinones. These findings led to the development of new versatile reagents, diphenyl 2-oxo-3-oxazolinylphosphonate [DPPOx] and 3-acyl- and 3-alkoxycarbonyl-2-oxazolones as well as their homo- and copolymers reactive enough to serve as highly chemo- and regioselective acylating agents. The DPPOx provides one-step and high-yield routes to 3-acyloxazolides, peptides, β-lactams, thiol esters and esters from a wide variety of carboxylic acids.<BR>Scope and advantages of these “ready-to-use” type reagents newly introduced are discussed from a preparative point of view.
- 社団法人 有機合成化学協会の論文
著者
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廣部 雅昭
東京大学薬学部
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広部 雅昭
東京大学薬学部:文部省
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国枝 武久
Faculty Of Pharmaceutical Sciences University Of Tokyo
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国枝 武久
東京大学薬学部
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