Studies on the Oxidation of N-Substituted-dibenz [b, f] azepines. II. Syntheses and Reactions of 5H-Dibenz [b, f] azepine 10,11-Oxides

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概要

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• The oxidation of various 5H-N-alkyl-10,11-substituted-dibenz [b, f] azepines with m-chloroperbenzoic acid (m-CPBA) was examined. The oxidation of 5H-N-benzyl-10-substituted-dibenz [b, f] azepine (V) gave N-benzyl-9-formyl-9-substituted-9H, 10H-acridine (VI), while the oxidation of 5H-N-benzyl-10,11-disubstituted-dibenz [b, f] azepine (VII) gave the corresponding 10,11-oxide (VIII). The chemical reactivities with several nucleophiles and the acid-catalyzed reactions of 5H-dibenz [b, f] azepine 10,11-oxides are also discussed.

• 社団法人日本薬学会の論文
• 1984-10-25

著者

• 広部 雅昭

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 宮田 直樹

  National Institute Of Hygienic Sciences University Of Tokyo

• 大田 富夫

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 宮田 直樹

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 大田 富夫

  Tokyo Research Laboratories Kowa Co. Ltd.

• 広部 雅昭

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 広部 雅昭

  東京大学薬学部:文部省

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