Disulfide Cleavage and Insulin Denaturation by Active Oxygen in the Copper(II)/Ascorbic Acid System
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概要
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Cupric ion catalytically enhances the autoxidation of L-ascorbic acid. The cleavage of disulfide occurred in the copper(II)/ascorbic acid system and was inhibited by catalase and by scavengers of hydroxyl radical, so that the hydroxyl radical was considered to be formed and to cleave the disulfide. Insulin was denatured by this system, but in this case the inhibitors were less effective. It seems likely that cupric ion was bound to insulin and that locally generated hydroxyl radical caused the damage. Cytokinins, which are plant growth regulators and retard leaf senescence, effectively inhibited the above reactions in the copper(II)/ascorbic acid system.
- 1986-03-25
著者
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広部 雅昭
Faculty of Pharmaceutical Sciences, University of Tokyo
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広部 雅昭
Faculty Of Pharmaceutical Sciences University Of Tokyo
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井上 英史
Faculty Of Pharmaceutical Sciences University Of Tokyo
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