A New Method for the Synthesis of 3-Chromanol Derivatives by Sodium Iodide-Catalyzed Cyclization of Epoxide
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概要
- 論文の詳細を見る
Treatment of 2-(2,3-epoxy)propylphenyl acetate derivatives with catalytic amounts of NaI in organic solvent gave directly the corresponding 3-chromanyl acetate derivatives in good yields (86.6-98.0%). Similar treatment of 2-(2,3-epoxy)propyl-6-methoxyphenyl N-mesyl-L-phenylalanylate gave a diastereomeric mixture of 8-methoxy-3-chromanyl N-mesyl-L-phenylalanylate, which was fractionated into both diatereomers by silica gel column chromatography. Subsequent hydrolysis of these isomers afforded the enantiomers of 8-methoxy-3-chromanol.
- 公益社団法人日本薬学会の論文
- 1990-08-25
著者
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大田 富夫
Tokyo Research Laboratories Kowa Co. Ltd.
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川村 清
Tokyo Research Laboratories Kowa Company Ltd.
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大谷 元治
Tokyo Resrarch Laboratories, Kowa Company, Ltd.,
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大谷 元治
Tokyo Research Laboratories Kowa Company Ltd.
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