ACTIONS OF DOPAMINE AND ITS DERIVATIVES ON THE TAENIA CAECUM AND TRACHEAL MUSCLE FROM THE GUINEA PIG AND THE VAS DEFERENS FROM THE RAT
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概要
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It is generally accepted that norepinephrine and epinephrine exert their physiological actions by reacting with two distinct types of adrenergic receptors, α- and β-receptors. Dopamine differs from norepinephrine in not having the hydroxyl group in the side chain. It has been found that dopamine in the peripheral tissues evokes a different type of effect, as fall in blood pressure in dog, guinea pig and rabbit (1-5). Specific dopamine receptors in the renal and mesenteric vessels of the dog were proposed (6).<BR> The aim of this paper is to determine if dopamine and its derivatives have specific dopamine receptors in the taenia caecum and tracheal muscle from the guinea pig and the vas deferens from the rat. Furthermore, the role of dopamine in the intestinal smooth muscle will be discussed in this paper.<BR> Some of the results has been briefly reported at the 46 general meeting of the Physiological Society of Japan (7).
- 社団法人 日本薬理学会の論文
著者
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高木 敬次郎
Department Of Pharmacotherapeutics Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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高木 敬次郎
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(present
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高柳 一成
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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高柳 一成
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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太田 和子
Division of Organic Chemistry, Tokyo Womens Medical College
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太田 和子
Division of Organic Chemistry, Tokyo Women's Medical College
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高柳 一成
Department of chemical Pharmacdogy, Faculty of Pharmaceutical Sciences, University of Tokyo
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高木 敬次郎
Department of chemical Pharmacdogy, Faculty of Pharmaceutical Sciences, University of Tokyo
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