モノアミン酸化酵素阻害剤の研究(第3報) : 直鎖脂肪族1級アルコールおよびアミンの作用

概要

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Activities of aliphatic primary alcohols and amines on rat liver monoamine oxidase were investigated. Aliphatic alcohols and amines inhibited monoamine oxidase and, as the number of carbon atoms increased, 50% inhibitory concentration decreased. Comparison of the inhibitory activities of alcohols and amines showed that amines inhibited monoamine oxidase at lower concentration than alcohols having the same number of carbon atoms. Moreover, while the inhibitory action of alcohols was reversible, that of amines was partially irreversible. These results suggest some specific affinity of amines on monoamine oxidase. Some of aliphatic amines were oxidized by monoamine oxidase and a part of their inhibitory action on monoamine oxidase was proved to be the attack of active center of the enzyme, but the inhibitory action of aliphatic alcohols and amines was estimated to be mainly non-competitive.
公益社団法人日本薬学会の論文
1966-06-25