モノアミン酸化酵素阻害剤の研究(第4報) : 非特異的酵素阻害の検討

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概要

• 論文の詳細を見る

• Inhibitory action of several compounds on rat liver monoamine oxidase was investigated according to Ferguson's rule and Mullins' hypothesis. Aliphatic primary alcohols, their acetates, aralkyl alcohols, phenethylamines, and piperidinoacetophenones decreased monoamine oxidase activity to about one-half of non-treated preparation at the concentration giving thermodynamic activities of 10^<-1> to 10^<-2>. These results suggest that these compounds might be classified as drugs having a "physical toxicitiy" and affected monoamine oxidase by their physicochemical properties. Volume fractions of alcohols were also calculated and a theoretical curve calculated from δ_<blo>=11.5 and XV=6.7 fltted the experimental values.

• 公益社団法人日本薬学会の論文
• 1966-06-25

著者

• 五味 保男

  東京大学薬学部

関連論文

• モノアミン酸化酵素阻害剤の研究(第4報) : 非特異的酵素阻害の検討
• モノアミン酸化酵素阻害剤の研究(第3報) : 直鎖脂肪族1級アルコールおよびアミンの作用
• モノアミン酸化酵素阻害剤の研究(第2報) : Phenethylamine誘導体の作用
• Preparation of Tyrosol and 4-Methoxyphenethyl Alcohol.

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