BETA-ADRENERGIC BLOCKER, 2-(2-HYDROXY-3-TERT-BUTYLAMINOPROPOXY) CHLOROBENZENE HYDROCHLORIDE (D-69-12)
スポンサーリンク
概要
- 論文の詳細を見る
The concept of two adrenergic receptor mechanisms or α- and β-adrenergic receptor systems, originally proposed by Ahlquist (1) was based on orders of potency of a series of catecholamines. Since dichloroisoprenaline (DCI) was introduced as a new category of drugs that selectively blocked the response due to β-adrenergic activation, several β-adrenergic blockers were found. In this paper 2-(2-hydroxy-3-tert-butylaminopropoxy) chlorobenzene hydrochloride (D-69-12) has been found to be a potent β-adrenergic blocker. However, D-69-12 in very high concentrations relaxed the smooth muscle preparations. So mode of action of D-69-12 was examined. Furthermore, the dual action of D-69-12 on the smooth muscle preparations has been discussed in this paper.
- 社団法人 日本薬理学会の論文
著者
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高木 敬次郎
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(present
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高柳 一成
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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梶原 良夫
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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平松 義郎
Pharmacological Research Department, Teikoku Hormone NFG. Co. Ltd.
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和泉 昭弘
Pharmacological Research Department, Teikoku Hormone NFG. Co. Ltd.
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和泉 昭弘
Pharmacological and Chemical Research Departments, Teikoku Hormone Mfg. Co. Ltd.
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平松 義郎
Pharmacological and Chemical Research Departments, Teikoku Hormone Mfg. Co. Ltd.
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高柳 一成
Department of chemical Pharmacdogy, Faculty of Pharmaceutical Sciences, University of Tokyo
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高木 敬次郎
Department of chemical Pharmacdogy, Faculty of Pharmaceutical Sciences, University of Tokyo
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