Studies on 1,2,3,4-Tetrahydroisoquinolines. IV. β-Adrenoceptor Activity and Absolute Stereochemistry of (-)-5,7-Dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

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概要

• 論文の詳細を見る

• Racemic 5,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline [(±) -1], a positional isomer of trimetoquinol (TMQ) with respect to its dihydroxy moiety, has been optically resolved. The bronchodilating activity in anesthetized cats (i.v. administration) was found to reside in the levorotatory enantiomer [(-) -1]. The absolute stereochemistry of the active enantiomer [(-) -1] was determined to be S by X-ray crystallographic analysis.

• 社団法人日本薬学会の論文
• 1982-05-25

著者

• 海野 徳英

  田辺製薬株式会社有機化学研究所

• 伊藤 信夫

  Research Laboratories Tanabe Seiyaku Co. Ltd.

• 池沢 一郎

  Research Laboratories Tanabe Seiyaku Co. Ltd.

• 山田 幸一郎

  Research Laboratories, Tanabe Seiyaku, Co., Ltd.

• 武田 幹男

  Research Laboratories, Tanabe Seiyaku, Co., Ltd.

• 海野 徳英

  Research Laboratories, Tanabe Seiyaku, Co., Ltd.

• 清本 昭夫

  Research Laboratories, Tanabe Seiyaku, Co., Ltd.

• 青江 啓一

  Research Laboratories, Tanabe Seiyaku, Co., Ltd.

• 小寺 啓司

  Research Laboratories, Tanabe Seiyaku, Co., Ltd.

• 岩隈 建男

  Research Laboratories, Tanabe Seiyaku, Co., Ltd.

• 清本 昭夫

  Research Laboratories Tanabe Seiyaku Co. Ltd.

• 海野 徳英

  Research Laboratories Tanabe Seiyaku Co. Ltd.

• 山田 幸一郎

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 小寺 啓司

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co Ltd.

• 武田 幹男

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 青江 啓一

  Organic Chemistry Research Laboratory:tanabe Seiyaku Co. Ltd.

• 武田 幹男

  田辺製薬株式会社有機化学研究所

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