Asymmetric Reduction of Various Ketones with the Sodium Salts of α-Amino Acid Borane Complexes
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概要
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The sodium salts of amino acid borane complexes (1) produced from equimolar amount of NaBH_4 and optically active α-amino acids in tetrahydrofuran at room temperature reduced various ketones to the corresponding optically active alcohols (2-62% optical yield). Sodium prolinate borane complex (2) gave the best results. Asymmetric reduction of (3) with sodium L-prolinate borane complex (2) followed by catalytic hydrogenolysis of benzyl and carbobenzoxy groups gave (4), a cardiotonic agent, in 62% optical yield.
- 社団法人日本薬学会の論文
- 1979-06-25
著者
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海野 徳英
田辺製薬株式会社有機化学研究所
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伊藤 信夫
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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伊藤 信夫
Research Laboratories Tanabe Seiyaku Co. Ltd.
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岩隈 建男
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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岩隈 建男
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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海野 徳英
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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