Asymmetric Reduction of Aromatic Ketones. I. Enantioselective Synthesis of Denopamine

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概要

• 論文の詳細を見る

• Asymmetric reduction of the N-protected amino ketone (2) with serveral chiral reducing agents, i.e., (R)-(+)-2-amino-3-methyl-1,1-diphenylbutanol (6)-borane complex (method A), (S, S')-N, N'-dibenzoylcystine (7)-LiBH_4-ROH complex (method B), and sodium (S)-prolinate-borane complex (8) (method C), was investigated in an attempt to synthesize denopamine (1) enantioselectively. Reduction of 2f by method B in tetrahydrofuran at 2-3℃ gave the best result (88% ee with 95% chemical yield).

• 社団法人日本薬学会の論文
• 1993-04-15

著者

• 松木 健司

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 武田 幹男

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 川口 隆行

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 斉藤 邦夫

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 岩隈 建男

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 斉藤 邦夫

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 岩隈 建男

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 武田 幹男

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 松木 健司

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

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