Studies on Antiallergic Agents. I. Phenyl-substituted Heterocycles with a 5-Tetrazolyl or N-(5-Tetrazolyl) carbamoyl Group
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概要
- 論文の詳細を見る
A series of phenyl-substituted pyrones, pyridines, and pyrimidines bearing a 5-tetrazolyl or N-(5-tetrazolyl) carbamoyl group as an acidic moiety was synthesized. The compounds were tested for antiallergic activity by passive cutaneous anaphylaxis (PCA) assay in rats after oral administration. Among the compounds synthesized. N-(5-tetrazolyl)-6-phenylpyridine-2-carboxamides (53,54 and 55) were found to display remarkably high potency.
- 社団法人日本薬学会の論文
- 1982-12-25
著者
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武田 幹男
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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関根 康雄
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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本間 靖
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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関根 康雄
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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橋山 富樹
Organic Chemistry Research Laboratory
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小野 保利
Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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黒葛原 啓
Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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関根 康雄
タナベセイヤク
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黒葛原 啓
R & D Planning Division Tanabe Seiyaku Co. Ltd.
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橋山 富樹
Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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本間 靖
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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武田 幹男
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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小野 保利
Pharmacological Research Laboratory Tanabe Seiyaku Co. Ltd.
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Tsuzurahara K
R & D Planning Division Tanabe Seiyaku Co. Ltd.
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橋山 富樹
Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.
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Hashiyama Tomiki
Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.
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