61 十字交差環化反応を用いるアルカロイド類の合成

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概要

• 論文の詳細を見る

• Recently, we have found the novel annulation reaction. When a molecule has 1,3-dicarbonyl group and a primary amino side chain, as shown in general scheme(1-4), formation of carbinolamine, retroaldol type of ring-opening, and transannular ring-closure under basic condition have sequentially occurred, and also briefly depicted by a crisscross sign indicating reaction sites in formula 5. Accordingly, we would like to name this reaction as the criaacross annulation. In case of secondary amine 1(R=alkyl), this reaction is nicely controlled to afford the medium-sized lactam 3. The crisscross annulation has been proved to be effective for the synthesis of pyrrolizidine 6, indolizidine 7, hydroazocine 8, pyrroloindole 9, and hydro-1-benzazocine 10.

• 天然有機化合物討論会の論文
• 1981-09-10

著者

• 関根 康雄

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 小田 邦幸

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 関根 康雄

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 大沼 毅

  北大・薬:(現)ブリストル・マイヤーズ研究所(株)

• 関根 康雄

  北大・薬

• 椎谷 恵子

  北大・薬

• 田部 昌泰

  北大・薬

• 小田 邦幸

  北大・薬

• 伴 義雄

  北大・薬

• 関根 康雄

  タナベセイヤク

• 伴 義雄

  東邦大・薬

• 伴 義雄

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 小田 邦幸

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

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