New Synthesis of Pyrrolo-1,4-benzodiazepines by Utilizing Palladium-Catalyzed Carbonylation

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概要

• 論文の詳細を見る

• A pyrrolo-1,4-benzodiazepine skeleton which constitutes the common part of a series of antibiotics exhibiting antitumor activity was synthesized by insertion of carbon monoxide into o-bromoprolylaniline derivatives in the presence of a catalytic amount of Pd (OAc)_2 and PPh_3. In this reaction, hexamethylphosphoramide (HMPA) gave a good result as the solvent and the use of a high pressure of carbon monoxide (5 atom) increased the yield of the desired pyrrolo-1,4-benzodiazepine.

• 公益社団法人日本薬学会の論文
• 1984-10-25

著者

• 伴 義雄

  Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University

• 石倉 稔

  Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University

• 石倉 稔

  Faculty Of Pharmaceutical Sciences

• 森 美和子

  北大・薬

• 伴 義雄

  東邦大・薬

• 伴 義雄

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 森 美和子

  Faculty of Pharmaceutical Sciences, Hokkaido University

• PURVANECKAS GEDIMINAS

  Faculty of Pharmaceutical Sciences, Hokkaido University

• Purvaneckas Gediminas

  Faculty Of Pharmaceutical Sciences Hokkaido University:(present Address)department Of Organic Chemis

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