The Reactions and Syntheses with Organometallic Compounds. II. The Deallylation Reaction with Pd^<II> and a New Synthesis of Primary Amines

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概要

• 論文の詳細を見る

• The N-(allyl) C bond of N-acyl-alkyl-allylamines could be easily cleaved by a stoichiometric amount of Pd^<II> in AcOH at 80°to afford the acyl derivatives of the primary amines and π-allyl palladium complex, the latter of which was attacked by the nucleophiles to furnish the unsaturated carbonyl compounds and Pd (0). An above amount of Pd^<II> could be replaced by a catalytic amount of PdCl_2 combined with a sufficient amount of inexpensive reagents, that are CuCl_2 and AcONa. Thus, this method is applied to a new synthesis of primary amines from the corresponding alkyl halides.

• 公益社団法人日本薬学会の論文
• 1976-09-25

著者

• 森 美和子

  北大・薬

• 伴 義雄

  東邦大・薬

• 伴 義雄

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 森 美和子

  Faculty of Pharmaceutical Sciences, Hokkaido University

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