Fluorescence and Structure of Proteins as measured by Incorporation of Fluorophore. II. Synthesis of Maleimide Derivatives as Fluorescence-Labeled Protein-Sulfhydryl Reagents.
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概要
- 論文の詳細を見る
A novel approach to studies of structure and function of proteins utilizing fluorescencelabeled specific reagent is proposed. N-[p-(2-Benzoxazolyl) phenyl] maleimide (IIIa) and N-[p-(2-benzthiazolyl) phenyl] maleimide (IIIb) were synthesized as sulfhydryl reagents of this type and the addition reaction with cysteine ester was investigated. Cyclization of maleamic acids with PPA is demonstrated to be a good method for synthesis of N-substituted maleimides.
- 公益社団法人日本薬学会の論文
- 1967-11-25
著者
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金岡 祐一
Faculty of Pharmaceutical Sciences, Hokkaido University
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伴 義雄
Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University
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伴 義雄
Faculty Of Pharmaceutical Sciences Hokkaido University
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伴 義雄
School Of Pharmaceutical Science Toho University
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町田 実
Faculty of Pharmaceutical Sciences, Hokkaido University
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町田 実
Formulation Technology Lab. Development & Technology Div. Chugai Pharmaceutical Co. Ltd.
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関根 隆光
Medical School, Juntendo University
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