Synthesis of μ-Conotoxin GIIIA : A Chemical Probe for Sodium Channels

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概要

• 論文の詳細を見る

• μ-Conotoxin GIIIA, a 22 amino acid peptide paralytic toxin which inhibits the muscle voltage-activated sodium channels, was synthesized by a solid phase method. No purification of intermediates was necessary for the synthesis, and a simple air oxidation of the deprotected crude peptide gave the desired toxin. By all criteria applied, the synthetic material was indistinguishable from the authentic natural toxin.

• 公益社団法人日本薬学会の論文
• 1990-01-25

著者

• 畑中 保丸

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 金岡 祐一

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 中山 仁

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 吉田 栄一

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 金岡 裕一

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 畑中 保丸

  富山医科薬学大学和漢薬研究所

• 畑中 保丸

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 中山 仁

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 中山 仁

  北大薬

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