Oxidation of Pyrroles with Benzoyl Peroxide : Synthesis of Mono- and Dihydroxypyrrole O-Benzoates and Oxidative Cleavage of Pyrrole-2-methanols

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概要

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• Benzoyl peroxide converts pyrroles into 2-hydroxy-and 2,5-dihydroxy O-benzoates. The mono-and di-O-benzoates of N-substituted pyrroles were prepared by this convenient one-step procedure. The mechanism was discussed in terms of both homolytic and heterolytic factors, and general aspects of homolytic substitution of the pyrrole ring were also discussed in comparison with other five-membered heterocycles. On treatment with benzoyl peroxide N-substituted pyrrole-2-methanols undergo novel C-C cleavage to give the O-benzoates.

• 公益社団法人日本薬学会の論文
• 1975-11-25

著者

• 金岡 祐一

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 金岡 祐一

  Toyama Women's College

• 相浦 真人

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 相浦 真人

  Faculty Of Pharmaceutical Sciences Hokkaido University

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