Comparative Studies on the Stability of Acyl Enzyme Intermediates : An Approach to the Design of Temporary Inhibitors for Trypsin-like Enzymes

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概要

• 論文の詳細を見る

• The deacylation rates of hydrolysis of inverse substrates (p-amidinophenyl esters) catalyzed by trypsin, thrombin and plasmin were studied from the standpoint of designing inhibitors which can discriminate between trypsin-like enzymes. It was shown that plasmin and thrombin behave quite differently towards these substrates; plasmin affords more stable acyl enzymes with aromatic acyl groups than with aliphatic acyl groups, while thrombin shows the opposite behavior. The half-life time of p-methoxybenzoyl plasmin is as long as 15 h while that of p-methoxybenzoyl thrombin is 35 min. This approach seems promising for the design of selective inhibitors of trypsin-like enzymes.

• 公益社団法人日本薬学会の論文
• 1986-02-25

著者

• 金岡 祐一

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 谷沢 和隆

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 金岡 裕一

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 谷沢 和隆

  Faculty Of Pharmaceutical Sciences Hokkaido University

• MCLAREN ASHLEY

  Lucas Heights Research Laboratories, Australian Atomic Energy Commission

• LAWSON WILLIAM

  Wadsworth Center for Laboratories and Research, New York State Department of Health

• Lawson William

  Wadsworth Center For Laboratories And Research New York State Department Of Health

• Mclaren Ashley

  Lucas Heights Research Laboratories Australian Atomic Energy Commission

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