Synthesis of a Key Fluorogenic Amide, L-Arginine-4-methylcoumaryl-7-amide (L-Arg-MCA) and Its Derivatives. Fluorescence Assays for Trypsin and Papain

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概要

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• L-Arginine-4-methylcoumaryl-7-amide 2 and its derivatives, which contain 7-amino-4-methylcoumarin 1 as a key fluorescence amine, were synthesized. The L-antipodes of N^α-benzoyl and N^α-carbobenzoxy derivatives were shown to be the useful fluorogenic substrates for the sensitive determinations of trypsin and papain.

• 公益社団法人日本薬学会の論文
• 1977-11-25

著者

• 高橋 哲夫

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 金岡 祐一

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 中山 仁

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 高田 克己

  Peptide Institute Protein Research Foundation

• 木村 皓俊

  Peptide Institute, Protein Research Foundation

• 榊原 俊平

  Peptide Institute, Protein Research Foundation

• 中山 仁

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 榊原 俊平

  ペプチド研

• 木村 皓俊

  ペプチド研

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