Inverse Substrates. IX. Amidinophenyl Esters derived from Amino Acids and Peptides : Synthesis and Properties as Trypsin Substrates

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概要

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• Methods for the preparation of p-amidinophenyl esters from amino acid derivatives are described. Blocking of the amidino function with the benzyloxycarbonyl group and its deblocking by catalytic hydrogenation after coupling were satisfactory. p-Amidinophenyl esters are of special interest because of their susceptibility to the hydrolytic enzyme, trypsin, and some parameters of the hydrolysis of these compounds by trypsin are presented.

• 1980-06-25

著者

• 金岡 祐一

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 中山 仁

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 谷沢 和隆

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 藤岡 聡之

  Faculty of Pharmaceutical Sciences, Mukogawa University

• 谷沢 和隆

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 藤岡 聡之

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 中山 仁

  Faculty Of Pharmaceutical Sciences Hokkaido University

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