Photochemical Synthesis of a Pyridopyrrolo [2,1-α] isoindole System by Cyclization of N-Methylpyridylphthalimides

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概要

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• Photochemical reactions of N-methylpyridylphthalimides (VII-IX) were investigated. Although irradiation of VII in an acetone solution gave only the dihydro product, 3-hydroxy-2-(3-methyl-2-pyridyl) phthalimidine (X), VIII afforded the expected cyclized product, 10b, 11-dihydro-10b-hydroxy-6H-pyrido [4', 3' : 4,5] pyrrolo [2,1-a] isoindol-6-one (XII) and dihydro product, 3-hydroxy-2-(4-methyl-3-pyridyl) phthalimidine (XI). Under similar conditions, the cyclized product, 10b, 11-dihydro-10b-hydroxy-6H-pyrido [3', 4' : 4,5]-pyrrolo [2,1-a] isoindol-6-one (XIII) was obtained from the photolysis of IX and none of the reduced product was isolated.

• 公益社団法人日本薬学会の論文
• 1977-07-25

著者

• 金岡 祐一

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 金岡 祐一

  Toyama Women's College

• 寺島 正直

  Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University

• 関 與一

  Faculty Of Pharmaceutical Sciences Higashi Nippon Gakuen University

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