Photodecarboxylation of N-Phthaloyl-α-amino Acids

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概要

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• N-Phthaloylglycine (1a) was irradiated with a high pressure mercury lamp to give N-methylphthalimide (2a) in an excellent yield. N-Phthaloyl derivatives 1b-k of other α-amino acids also afforded the decarboxylated products 2b-k. In the cases of N-phthaloylserine (1l) and di-phthaloylcystine (1m), N-vinylphthalimide (3) was isolated as a major product. On the other hand, N-phthaloylmethionine (11a) and methyl N-phthaloylmethionate (11b) were treated in the same manner to give the aza-thiacycloheptanol derivatives 12a-b having a new ring system. Solvent effects and possible pathways of these reactions were examined.

• 公益社団法人日本薬学会の論文
• 1982-04-25

著者

• 仲井 英雄

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 佐藤 泰彦

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 溝口 富茂

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• 畑中 保丸

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 金岡 祐一

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 佐藤 泰彦

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 仲井 英雄

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 仲井 英夫

  田辺製薬研

• 中井 英雄

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 溝口 富茂

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• Nakai H

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 金岡 祐一

  Toyama Women's College

• 川西 正純

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 畑中 保丸

  富山医科薬学大学和漢薬研究所

• 畑中 保丸

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 川西 正純

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

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