Use of N, S-Bis-tert-butoxycarbonyl-L-cysteine for Synthesis of Glutathione
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概要
- 論文の詳細を見る
N, S-Bis-tert-butoxycarbonyl-L-cysteine (I), a novel protected cysteine derivative, is proposed for glutathione synthesis. I was obtained in one step reaction from L-cysteine and tert-butoxycarbonyl chloride. The reaction of tert-butoxycarbonyl azide with L-cysteine also gave I but in low yield. The protecting groups on the nitrogen and sulfur atoms of I are stable under the usual conditions used in peptide synthesis and can be removed selectively by mild acidic or alkaline conditions. These groups are also removed simultaniously by a strong acidic reagent such as hydrogen chloride of high concentration in acetic acid. Synthesis of glutathione was performed employing I as a new type of intermediate.
- 公益社団法人日本薬学会の論文
- 1971-08-25
著者
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村木 正義
田辺製薬株式会社有機化学研究所
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溝口 富茂
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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溝口 富茂
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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村木 正義
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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