Novel Fluorogenic Substrates Containing Bimane System for Microdetermination of Angiotensin I Converting Enzyme

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概要

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• As a sensitive fluorometric assay for the activity of angiotensin converting enzyme, bimane-peptides containing tryptophan, i.e., 1,7-dioxo-2,5,6-trimethyl-1H, 7H, pyrazolo[1,2-α]pyrazol-3-yl-methylthiomethylcarbonyl-glycyl (or L-phenylalanyl)-L-tryptophyl-L-leucine (or L-proline), were synthesized and shown to be potent fluorogenic substrates for the micro-determination of angiotensin I converting enzyme activity.

• 1989-01-25

著者

• 金岡 祐一

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 金岡 裕一

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 佐藤 英助

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 佐藤 英助

  Faculty Of Pharmaceutical Sciences Hokkaido University:(present Address)department Of Technology Aom

• 西川 さと子

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 西川 さと子

  Faculty Of Pharmaceutical Sciences Hokkaido University

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