Hydrolysis of N-Substituted Maleimides : Stability of Fluorescence Thiol Reagents in Aqueous Media
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概要
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p-Substituted phenylmaleimides were synthesized and their hydrolytic rates were measured by dual-wavelength method. Hammett plot for the hydrolysis of p-substituted phenylmaleimide yields a straight line of p=0.35 with relative coefficiency r=0.99. The half-life times of a series of maleimide derivatives including the practical fluorescent thiol reagents such as N-[p-(2-benzimidazolyl) phenyl] maleimide, N-(1-anilinonaphthyl-4)-maleimide and N-(7-dimethylamino-4-methyl-3-coumarinyl) maleimide were compared and their stabilities in aqueons media were discussed.
- 公益社団法人日本薬学会の論文
- 1977-10-25
著者
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金岡 祐一
Faculty of Pharmaceutical Sciences, Hokkaido University
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金岡 祐一
Toyama Women's College
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町田 實
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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