Characterization of Saccharide Moiety in the Electroplax Sodium Channel

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概要

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• Carbohydrate chains on the large peptide of the voltage-sensitive sodium channel from Electrophorus electricus electroplax have been partially characterized by the lectin-blotting technique combined with digestion using three glucosidases : neuraminidase, engo-β-N-acetylglucosaminidase H, and peptide : N-glycosidase F. The results show that both N-linked oligosaccharides and O-linked (mucin-type) oligosaccharides are present. In N-linked oligosaccharides, the results suggest the presence of complex-and hybrid-type oligosaccharides which contain bisecting N-acetylglucos-amine(s), as well as the complex-type oligosaccharides with the α-Fuc-GlcNAc-(Asn) residue(s). In O-linked oligosac-charides, they must carry Galβ1→3GalNAc- moieties which contain NeuNAc residues in the terminal.

• 公益社団法人日本薬学会の論文
• 1992-12-25

著者

• 畑中 保丸

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 金岡 祐一

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 崎山 文夫

  Institute for Protein Research, Osaka University

• 中山 仁

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 山本 茂樹

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 金岡 裕一

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 蓮 哲昭

  Institute for Protein Research, Osaka University

• 綱沢 進

  Institute for Protein Research, Osaka University

• 畑中 保丸

  富山医科薬学大学和漢薬研究所

• 畑中 保丸

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 中山 仁

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 中山 仁

  北大薬

• 綱沢 進

  Institute For Protein Research Osaka University

• 蓮 哲昭

  Institute For Protein Research Osaka University

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