Synthesis of Diazipine and [^3H]Diazipine : Novel dihydropyridines as Photoaffinity Probes of Calcium Channels

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概要

• 論文の詳細を見る

• Diazipine and [^3H]diazipine were synthesized as new 1,4-dihydropyridine photoaffinity ligands containing a phenyldiazirine group. After simple high performance liquid chromatography separation, both compounds were purified in good overall yields. [^3H]Diazipine (21.2Ci/mmol) was synthesized in two steps from commercially available [^3H]ethanolamine. Diazipine competitively inhibited [^3H]PN200-110 binding to the calcium channel of cardiac membranes with high affinity.

• 社団法人日本薬学会の論文
• 1991-07-25

著者

• 中山 仁

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 國安 明彦

  熊本大学 薬学部 生体機能化学

• 瀧 基彦

  Facutly of Pharmaceutical Sciences, Hokkaido Univeristy

• 國安 明彦

  Facutly of Pharmaceutical Sciences, Hokkaido Univeristy

• 中山 仁

  Facutly of Pharmaceutical Sciences, Hokkaido Univeristy

• 金岡 祐一

  Facutly of Pharmaceutical Sciences, Hokkaido Univeristy

• 金岡 裕一

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 瀧 基彦

  Facutly Of Pharmaceutical Sciences Hokkaido Univeristy

• 中山 仁

  北大薬

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