分子としてのナトリウムチャンネル

概要

論文の詳細を見る
A sodium channel is well evaluated as a molecule which plays a key role in the nerve transmission since the excellent description by Hodgikin & Huxley on the basis of electrophysiological techniques in 1950s. Molecular entity of the channel, however, had not been thoroughly elucidated until the recent progress in biochemical approaches to purify it in a detergent-soluble form from eel electroplax, rat brain, and rat muscle. The purified channel protein from all three sources was reconstituted into phospholipid vesicles and shown to retain functional activity in a voltage dependent manner.<BR>In addition, the relevance of the complete amino acid sequence of the eel channel protein can be viewed as inagurating a new phase of research on the molecular properties of ion channels in which the molecular architecture of their functional components is elucidated at ever finer resolution. Current status and questions to be resolved of the sodium channel molecule are reviewed in the biochemical aspect.
日本生物物理学会の論文