The Fischer Indole Synthesis with Formic Acid. II. The Synthesis of Hexahydrocyclopent (b) indoles

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概要

• 論文の詳細を見る

• 2-Alkylcyclopentanone phenylhydrazones (Ia, b) were refluxed with 98-100% formic acid to solely afford cis-1 : 2 : 3 : 3a : 4 : 8b-hexahydro-8b-alkyl-cyclopent (b) indoles (IVa, b) in the yields of 34% and 33%, respectively. Similar treatment of cyclopentanone phenylhydrazone with formic acid gave indoline (IVc) and indoles (IIc) and its N-formyl derivative (IIe). The reaction mechanism and stereochemistry of these products are discussed.

• 公益社団法人日本薬学会の論文
• 1971-12-25

著者

• 伴 義雄

  Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University

• 大石 武

  Faculty Of Engineering Yokohama National University:(present Address)meiji College Of Pharmacy

• 伴 義雄

  東邦大・薬

• 伴 義雄

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 大石 武

  北大・薬:(現)理化学研究所

• 村上 信二

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 清水 条資

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 清水 条資

  Faculty Of Pharmaceutical Sciences Hokkaido University

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