A FACILE CHEMOENZYMATIC ROUTE TO ENANTIOMERICALLY PURE 4,5-DISUBSTITUTED-2-HEXENOATE DERIVATIVES

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概要

• 論文の詳細を見る

• The reaction of 4,5-epoxy-2-hexenoate 2__- and various nucleophiles in the presenece of BF_3.Et_20 predominantly gave the (4,5)-5-hydroxy-4-substituted compounds. Among them, (±)-(4,5)-anti-5-hydroxy-4-thiophenoxy ester 17 was enantioselectively esterified with acylating reagent in the presence of lipase "PL 266" from Alcaligenes sp. to provide the (4S, 5R)-5-acetoxy ester 20 and the (4R, 5S)-17 quantitatively.

• 社団法人日本薬学会の論文
• 1991-11-25

著者

• 秋田 弘幸

  School of Pharmaceutical Sciences, Toho University

• 松倉 弘子

  Riken Institute (The Institute of Physical and Chemical Research)

• 大石 武

  Riken Institute (The Institute of Physical and Chemical Research)

• 松倉 弘子

  Riken Institute(the Institute Of Physical And Chemical Research)

• 大石 武

  Faculty Of Engineering Yokohama National University:(present Address)meiji College Of Pharmacy

• 梅澤 勲

  School of Pharmaceutical Science, Toho University

• 大石 武

  理研:(現)明治薬科大学

• 秋田 弘幸

  School Of Pharmaceutical Science Toho University

• 秋田 弘幸

  理化学研究所

• 鷹野 道香

  Riken Institute(the Insitute Of Physical And Chemical Research)

• 梅澤 勲

  Riken Institute (The Institute of Physical and Chemical Research)

• 梅澤 勲

  School Of Pharmaceutical Science Toho University

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