Revised Stereostructure for (+)-Roemecarine and Synthesis of (±)-, (+)-, and (-)-Roemercarine and (±)-Epiroemecarine

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概要

• 論文の詳細を見る

• The stereostructure of (+)-roemecarine, a new 1-benzyl-1,2,3,4-tetrahydroisoquinoline having a hydroxyl group at the 4-position, was confirmed to be 1,4-trans by synthesis of (±)-epiroemecarine (1) and (±)-roemecarine (5) via o-quinol acetates of isocodamine (4). Furthermore, (+)- and (-)-roemecarine (5) were synthesized in good chemical and optical yields by kinetic resolution of (±)-4-O-acetyl- (3) or (±)-4,6-O, O-diacetylroemecarine (7) by the use of immobilized lipase OF-360 (Candida cylindracea) in organic solvents. (+)-Roemecarine (5) was proved to have 1S, 4S-configuration.

• 公益社団法人日本薬学会の論文
• 1990-12-25

著者

• 星野 修

  東京理科大学薬学部

• 秋田 弘幸

  School of Pharmaceutical Sciences, Toho University

• 秋田 弘幸

  Riken Institute (The Institute of Physical and Chemical Research)

• 大石 武

  Riken Institute (The Institute of Physical and Chemical Research)

• 大石 武

  Faculty Of Engineering Yokohama National University:(present Address)meiji College Of Pharmacy

• 星野 修

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 梅澤 文輔

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 大石 武

  理研:(現)明治薬科大学

• 伊藤 勝彦

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 秋田 弘幸

  School Of Pharmaceutical Science Toho University

• 秋田 弘幸

  理化学研究所

• 梅澤 文輔

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 棚橋 留香

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 星野 修

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 棚橋 留香

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

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