Studies on Tetrahydroisoquinolines. XXV. A Synthesis of 4-Aryl-1,2,3,4-tetrahydroisoquinolines ; Total Synthesis of (±)-Cherylline
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概要
- 論文の詳細を見る
Four 4-phenyl-1,2,3,4-tetrahydroisoquinolines (8b, c, f, g) were prepared from two simple synthons, styrene oxide and the benzylamines (2b-e), via the β-hydroxyphenethylamines (3b-e) in high yield. On the other hand, the β-methoxyphenethyl methanesulfonate (16), obtained from 4-benzyloxystyrene oxide (11), was coupled with the benzylamine (2a) to give the N-benzyl-β-methoxyphenethylamine (17). A facile total synthesis of (±)-cherylline (1) was accomplished by acid treatment of 17.4'-O-Methylcherylline (18) was also synthesized through the same pathway.
- 社団法人日本薬学会の論文
- 1985-08-25
著者
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星野 修
東京理科大学薬学部
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原 博
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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原 博
東京理科大学薬学部
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白井 隆一
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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星野 修
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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梅澤 文輔
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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梅澤 文輔
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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原 博
東京理大 薬
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白井 隆一
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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星野 修
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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