ENANTIOMERIC DIFFERENCE IN PERCUTANEOUS PENETRATION OF PROPRANOLOL THROUGH RAT EXCISED SKIN
スポンサーリンク
概要
- 論文の詳細を見る
The percutaneous penetration of R-(+)- and S-(-)-propranolol (PL) through rat excised skin was investigated in vitro. The flux of S-(-)-PL after application to normal skin was high compared with that of R-(+)-PL. On the other hand, in damaged rat skin, the flux of R-(+)-PL was almost equivalent to that of S-(-)-PL. It is suggested that there is an enantiomeric difference between S-(-)- and R(+)-PL in terms of penetration through rat stratum corneum.
- 社団法人日本薬学会の論文
- 1992-04-25
著者
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芳賀 信
東京理科大学薬学部
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原 博
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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芳賀 信
東京理大・薬
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加藤 百合子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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海保 房夫
東京理科大学薬学部
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宮崎 桂介
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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海保 房夫
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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稲垣 愛子
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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土肥 雅彦
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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櫨本 紀夫
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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芳賀 信
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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芳賀 信
Faculty Of Pharmaceutical Sciences Sciences University Of Tokyo
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櫨本 紀夫
(Present address)Faculty of Pharmaceutical Sciences, Nagoya City University
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土肥 雅彦
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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櫨本 紀夫
(present Address)faculty Of Pharmaceutical Sciences Nagoya City University
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稲垣 愛子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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