Pulverization Method for Sulfamethizole and Its Physicochemical Properties
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概要
- 論文の詳細を見る
Sulfamethizole was pulverized by recrystallization from glycols or their derivatives, and correlation of difference in the degree of pulverization with the solvent was studied. Crystalline properties of the pulverized crystals of sulfamethizole thus obtained were also studied. The degree of pulverization of sulfamethizole by recrystallization from glycols and their derivatives decreased with increase in the number of carbon atoms in the hydrophobic chain of these solvents. When the pulverized sulfamethizole were examined by IR, X-ray diffraction, and DSC-TG, two kinds of hydrate and one kind of anhydride were detected. The form I (anhydride) was transformed into form III (hydrate ; 1 mol H_2O) in the artificial gastric juice of 37°, but not in water.
- 公益社団法人日本薬学会の論文
- 1979-02-25
著者
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渡辺 久子
Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.,
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加藤 百合子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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渡辺 久子
Central Research Laboratories Banyu Pharmaceutical Co. Ltd.
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前山 直子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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渡辺 久子
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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木戸 和子
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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木戸 和子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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