The Determination of (α-Bromoisovaleryl) urea in Plasma and the Bioavailabilities of Its Polymorphic Forms in the Rat
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概要
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A simple and sensitive determination method for (α-bromoisovaleryl) urea in plasma was developed by using gas-liquid chromatography with an electron capture detector, (α-Bromoisovaleryl) urea was extracted from plasma with ethyl ether and ethanol in a ratio of 5 : 1 (volume); the recovery was 97.5%. The plasma concentrations were determined by the internal standard GLC-ECD method without further clean-up by column chromatography. The detection limit was about 0.5 μg/ml in 0.1 ml plasma. In order to determine the effect of polymorphism (form I, form II, and form III) of (α-bromoisovaleryl)-urea on the bioavailiabilities, plasma levels in rats after intraduodenal administration were investigated. The areas under the blood concentration curves (AUC) and the mean dissolution times (MDT) were calculated to determine the extent of bioavailability and the rate of bioavailability, respectively. The results indicated that the polymorphic states of (α-bromoisovaleryl) urea did not show significantly different bioavailabilities.
- 公益社団法人日本薬学会の論文
- 1982-05-25
著者
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際田 弘志
Faculty Of Pharmaceutical Sciences University Of Tokushima
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加藤 百合子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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小島 宏之
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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加藤 百合子
Japan and Faculty of Pharmaceutical Sciences, Science University of Tokyo
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新村 均
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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際田 弘志
Faculty Of Pharmaceutical Sciences Tokushima University
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加藤 百合子
Japan And Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Kiwada H
Faculty Of Pharmaceutical Sciences University Of Tokushima
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新村 均
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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