溶解補助剤の研究(第5報)グリコール類およびその誘導体と水との混液におけるNMRスペクトルの解析

概要

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When the chemical shift of the methyl-proton and methoxyl-proton is plotted against the concentration of a mixed solution of water with 1-methoxy-2-propanol, methylcarbitol, carbitol, cellosolve, dipropylene glycol, isopropylcellosolve, or hexylene glycol as the solubilizing agent, shift to a higher magnetic field is observed at a certain concentration in any of the mixtures. The plot of the chemical shift against dielectric constant of the mixed solution showed a linear relation between dielectric constant at ca. 15-45 and the chemical shift of methyl-proton and methoxyl-proton. Consequently, these mixed solutions are considered to undergo association at this concentration. In mixed solutions of water with 1-methoxy-2-propanol and hexylene glycol, a change in spin coupling state is seen in the methylene-proton at a specific concentration and this concentration is that at which the foregoing methyl- and methoxyl-protons show a shift to a higher magnetic field, and the same concentration at which an inflexion appeared in the plot of dielectric constant with solubility and physical properties. This phenomenon is considered to result from the association of the mixed solutions at this concentration.
公益社団法人日本薬学会の論文
1973-06-25