Effects of Water-Soluble Polymers on the Crystalline Conversion of Prednisolone in Oil-in-Water Type Ointment Bases
スポンサーリンク
概要
- 論文の詳細を見る
The effects of methylcellulose (MC) and hydroxypropylcellulose (HPC) on oil-in-water (o/w) type ointment bases and the crystalline conversion from the anhydrous form of prednisolone (A-PD) to its hydrated form (C-PD) in such o/w type ointment bases were studied. The weight loss of the base, that is the volume of water released from the base, was measured in dry conditions and at a low temperature (5℃). The weight loss of the base without MC or HPC (No.1 base) was about 7% in 10d. On the other hand, the weight losses of the base containing MC (No.3 base), and that containing HPC (No.6 base) were about 1% and 4% under the same conditions, respectively. The yield value of each of the bases Nos.1,3,and 6 was measured with a spreading meter. The yield value of No.1 base was smaller than that of the other bases for 24h after preparation at room temperature (25℃). The yield value of No.3 base became lower and that of No.6 base became slightly greater than that of 24 h for 7 d after preparation upon storage at room temperature and humidity (25℃). However, the yield value of No.1 base increased after 7 d. The crystalline conversion of A-PD in o/w type ointment base was measured by the use of an X-ray diffractometer. A-PD was entirely converted into C-PD in No.1 base in only 1 d at 5℃. On the other hand, when MC or HPC was incorporated in the base, the conversion of A-PD to C-PD was retarded. The periods required for complete crystalline conversion from A-PD to C-PD in the bases (Nos. 2-4) containing MC and the bases (Nos.5-7) containing HPC were about 20-30 d and 3-18 d, respectively. Furthermore, in vitro release of PD from No.1 base without MC and from No.2 base containing MC were studied for 24 h after preparation at 5℃. Since A-PD was entirely converted into C-PD after 24 h at 5℃, the amount of PD released from No.1 base was less than that of immediately after preparation, whereas the release pattern of PD from No.2 base was the same as that from the base immediately after preparation since crystalline conversion did not occur in No.2 base. In addition, the release of PD from No.4 base was studied for 10 d after preparation at 5℃. The amount of PD released from No.4 base after 10 d was the same as that of immediately after preparation, since crystalline conversion of PD did not occur in this base. Water-soluble polymers such as MC and HPC act as protective colloids, and so the structure of the emulsion in the ointment base is stabilized. The structure of the emulsion in the base including water-soluble polymer is stabilized even at low temperature where the o/w type emulsion structure normally deteriorates. It is suggested that water-soluble polymer is an effective additive to o/w type ointment bases.
- 公益社団法人日本薬学会の論文
- 1982-03-25
著者
-
石橋 照子
Faculty Of Pharmaceutical Sciences Sciences University Of Tokyo
-
加藤 百合子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
-
海保 房夫
東京理科大学薬学部
-
海保 房夫
Faculty of Pharmaceutical Sciences, Science University of Tokyo
関連論文
- α-オレフィンオリゴマーゲル基剤による薬物の経皮吸収
- Colorimetric Determination in the Frozen State with Dual-Wavelength Spectrophotometer. Application to the Kinetics of Hydrolysis of p-Nitrophenyl Acetate
- Studies on the Uptake Mechanism of Liposomes by Perfused Rat Liver. I. : An Investigation of Effluent Profiles with Perfusate Containing No Blood Component
- ENANTIOMERIC DIFFERENCE IN PERCUTANEOUS PENETRATION OF PROPRANOLOL THROUGH RAT EXCISED SKIN
- 坐剤からの薬物の直腸吸収に対するカプリン酸(C10)の促進作用
- 溶解補助剤の研究(第1報) : グリコール類およびその誘導体と水との混液の溶存酵素について
- Effect of Phosphatidylcholine and Cholesterol on pH-Sensitive Liposomes
- Enhancing Effects of Myristryl Lactate and Lauryl Lactate on Percutaneous Absorption of Indometacin in Rats
- Effects of Preparing and Ligand-Binding Methods of Small Unilamellar Liposomes on Their Blood Elimination and Tissue Distribution in Rats
- Hypoglycemic Effect of Intestinally Administered Monosaccharide-Modified Insulin Derivatives in Rats