フェノバルビタールの微細化
スポンサーリンク
概要
- 論文の詳細を見る
Phenobarbital was pulverized by recrystallization from glycols and their derivatives, and correlation of difference in the degree of pulverization with the solvent was studied. The crystalline form of the pulverized phenobarbital were also examined. The degree of pulverization of phenobarbital by recrystallization from glycols and their derivatives decreased with increase in the carbon atoms in the hydrophobic chain of these solvents. Two different solid phases (hydrate and form II) of pulverized phenobarbital were examined, and the hydrate (with 1 mol H_2O) was transformed into form II (anhydrate) on being kept in a desiccator under a reduced pressure at room temperature.
- 公益社団法人日本薬学会の論文
- 1978-01-25
著者
-
加藤 百合子
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
-
加藤 百合子
東京理科大学薬学部
-
松浦 正治
東京理科大学薬学部
関連論文
- α-オレフィンオリゴマーゲル基剤による薬物の経皮吸収
- Colorimetric Determination in the Frozen State with Dual-Wavelength Spectrophotometer. Application to the Kinetics of Hydrolysis of p-Nitrophenyl Acetate
- Studies on the Uptake Mechanism of Liposomes by Perfused Rat Liver. I. : An Investigation of Effluent Profiles with Perfusate Containing No Blood Component
- ENANTIOMERIC DIFFERENCE IN PERCUTANEOUS PENETRATION OF PROPRANOLOL THROUGH RAT EXCISED SKIN
- 溶解補助剤の研究(第1報) : グリコール類およびその誘導体と水との混液の溶存酵素について
- Effect of Phosphatidylcholine and Cholesterol on pH-Sensitive Liposomes
- Enhancing Effects of Myristryl Lactate and Lauryl Lactate on Percutaneous Absorption of Indometacin in Rats
- Effects of Preparing and Ligand-Binding Methods of Small Unilamellar Liposomes on Their Blood Elimination and Tissue Distribution in Rats
- Hypoglycemic Effect of Intestinally Administered Monosaccharide-Modified Insulin Derivatives in Rats
- Percutaneous Absorption of Indomethacin from Mixtures of Fatty Alcohol and Propylene Glycol (FAPG Bases) through Rat Skin : Effects of Oleic Acid Added to FAPG Base
- pH-Sensitive Liposomes Composed of Phosphatidylethanolamine and Fatty Acid
- An Improved Chemiluminescence-Based Liposome Immunoassay Involving Apoenzyme
- Plasma-Polymerized Membrane Electrode for the Determination of Dextromethorphan and Dimemorfan
- A Liposome Immunoassay Based on a Chemiluminescense Reaction
- Enhancing Effect of Cetyl Lactate on the Percutaneous Absorption of Indomethacin in Rats
- Tissue Distribution of Sialoglycopeptide-Bearing Liposmones in Rats
- Application of Synthetic Liposomes Based on Acyl Amino Acids or Acyl Peptides as Drug Carriers. I. Their Preparation and Transport of Glutathione into the Liver(Pharmaceutical)
- Percutaneous Absorption of Indomethacin from Mixtures of Fatty Alcohol and Propylene Glycol(FAPG Bases) through Rat Skin : Effects of Fatty Acid Added to FAPG Base(Pharmaceutical)
- Studies on the Uptake Mechanism of Liposomes by Perfused Rat Liver. II. : An Indispensable Factor for Liver Uptake in Serum(Pharmaceutical)
- A New Type of Enzyme Immunosensor Using Antigen-Bound Membrane and Multivalent Antibody (Fab'-α-Amylase Conjugate)(Analytical,Chemical)
- Feasibility of Magnetic Liposomes as a Targeting Device for Drugs
- Effects of Dose and Vesicle Size on the Pharmacokinetics of Liposomes
- Effects of Water-Soluble Polymers on the Crystalline Conversion of Prednisolone in Oil-in-Water Type Ointment Bases
- Effects of Phenylbutazone Analogues on the Plasma Concentration and Renal Excretion of Salicylate and Its Metabolites in Rabbits
- Relationship between Polymorphism and Bioavailability of Amobarbital in the Rabbit
- Microcrystallization Method for Amobarbital and the Physicochemical Properties of the Products
- Formation of a Micelle-like Structure in Aqueous Solution of 1,4-Hexanediol.
- Formation of a Micelle-like Structure in Aqueous Solution of Glycols.
- Tissue Distribution and Pharmacokinetic Evaluation of the Targeting Efficiency of Synthetic Alkyl Glycoside Vesicles
- Application of Synthetic Alkyl Glycoside Vesicles as Drug Carriers. I. Preparation and Physical Properties
- Correlations between in Vivo and in Vitro Dissolution Rates of (α-Bromoisovaleryl) urea Polymorphs
- Pharmacokinetic Study on the Polymorphs of (α-Bromoisovaleryl) urea in the Rat
- The Determination of (α-Bromoisovaleryl) urea in Plasma and the Bioavailabilities of Its Polymorphic Forms in the Rat
- The Dissolution Properties and Physico-chemical Properties of Polymorphic Forms of (α-Bromoisovaleryl) urea
- The Preparation and Properties of a New Polymorphic Form of (α-Bromoisovaleryl) urea
- Effect of Surface Modification of Liposomes with Sialoglycopeptide of Their Clearance from the Circulation
- 溶解補助剤の研究(第6報) グリコール類およびその誘導体と水との混液中アスコルビン酸の安定性について
- 高級アルコール類の製剤への応用(第3報) : 高級アルコールとプロピレングリコール混合物 (FAPG 基剤) によるインドメタシンの経皮吸収
- 溶解補助剤の研究(第2報) : グリコール類およびその誘導体と水との混液の性質について
- New Polymorphic Forms of Phenobarbital
- In Vitro Release of Prednisolone from Oil-in-Water Type Ointment. The Effect of Long-chain Alcohols on Drug Release
- フェノバルビタールの多形と生物学的利用率
- Displacement of Sulfonamides from Bovine Serum Albumin by Nonsteroidal Anti-inflammatory Drugs
- 非ステロイド性抗炎症薬の蛋白結合(第2報)サリチル酸の蛋白結合におよぼす種々の薬物の影響
- O/W型軟膏中におけるプレドニゾロンの結晶変化におよぼす高級アルコールの影響
- Pulverization Method for Sulfamethizole and Its Physicochemical Properties
- 家兎におけるサリチル酸の血漿中濃度および尿中排泄におよぼすフェニルブタゾンの影響
- Serum Protein Binding and Salivary Secretion of Salicylic Acid in Man
- フェノバルビタールの微細化
- Prediction of Plasma Protein Binding of Salicylic Acid in the Rabbit
- In Vitro Release of Prednisolone from Oil-in-Water Type Ointment. The Effect of Crystalline Conversion on Drug Release
- Solubility of a New Polymorph of Phenobarbital obtained by Crystallization in the Presence of Phenytoin
- 卒研生の教室配属(四年生の講座配属)
- ホモスルファミンの多形およびその含水型の安定性
- 溶解補助剤の研究(第5報)グリコール類およびその誘導体と水との混液におけるNMRスペクトルの解析
- 溶解補助剤の研究(第4報) : グリコール類およびその誘導体と水との混液中の薬品の溶解度と誘電率の関係について
- 溶解補助剤の研究(第3報) : グリコール類およびその誘導体と水との混液の性質について