Hypoglycemic Effect of Intestinally Administered Monosaccharide-Modified Insulin Derivatives in Rats

概要

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The effect of the modification of insulin (INS) with p-succinylamidophenyl (SA)-α-D-glucopyranoside (SAPG), SA-α-D-mannopyranoside and SA-α-L-arabinopyranoside on the enzymatic degradation and the hypoglycemic effect in rats was studied. When SAPG-INS was administered intraintestinally in the absence of bile and pancreatic juice, blood glucose level decreased to 56% of initial value. Other monosaccharide derivatives were less effective than SAPG-INS. The digestion of monosaccharide derivatives by pepsin and chymotrypsin indicated that the resistance of insulin to enzymatic degradation was increased by its modification with monosaccharide. One possibility for the hydroglycemic effect of SAPG-INS could be the increased resistance of insulin to enzymatic degradation as a result of its modification with monosaccharide.
公益社団法人日本薬学会の論文
1990-07-25