Species-Difference of Cyclooxygenase-2 in the Hippocampus of Rodents
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概要
- 論文の詳細を見る
Cyclooxygenase (COX) generates free radicals and it is important in inflammatory response. In this study, we observed the immunoreactivity in mice (ICR and C57BL/6 strain), rats and gerbils. In these animals, COX-2 immunoreactivity was mainly detected in pyramidal cells of the hippocampal CA2/3 region and in granule cells of the dentate gyrus. COX-2 immunoreactivity in the CA2/3 region was highest in ICR mice, while in gerbils COX-2 immunoreactivity was lowest; COX-2 immunoreactivity in the dentate gyrus was highest in rats and lowest in gerbils. The protein levels of COX-2 were similar to the immunohistochemical data. COX-2 mRNA transcript was the highest in the gerbil and the lowest in the rat. In brief, COX-2 protein, not mRNA, in the hippocampus is generally higher in mice (ICR and C57BL/6 strain) than rats and gerbils.
- 社団法人 日本獣医学会の論文
著者
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HWANG In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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CHOI Jung
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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YOO Ki-Yeon
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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LEE Choong
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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SEONG Je
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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YOON Yeo
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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WON Moo-Ho
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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Kim Sung
Department of Bioengineering and Technology, College of Engineering, Kangwon National University
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Seong Je
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Hwang In-koo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Yoo Dae
Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for V
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Hwang In
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Yoon Yeo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Lee Choong
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Choi Jung
Department Of Anatomy And Neurobiology College Of Medicine Hallym University
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Choi Ji
Department Of Pharmacology College Of Pharmacy Seoul National University
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Kim Sung
Department Of Anatomy
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SHIN Hyung-Cheul
Department of Physiology, College of Medicine, Hallym University
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Choi Ji
Department Of Cardiology College Of Medicine Catholic University Of Daegu
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Yoo Ki-yeon
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Choi Jung
Department Of Agricultural Biotechnology Seoul National University
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WON Moo-Ho
Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University
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Kim Sung
Department of Advanced Materials Engineering for Information and Electronics, Kyung Hee University, Yongin, Gyeonggi 446-701, Republic of Korea
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YOON Yeo
Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University
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YOO Dae
Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University
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CHOI Ji
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University
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CHOI Ji
Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University
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YOO Dae
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University
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CHOI Jung
Department of Anatomy and Neurobiology, Institute of Neurodegeneration and Neuroregeneration, Hallym University
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LEE Choong
Department of Anatomy and Neurobiology, Institute of Neurodegeneration and Neuroregeneration, Hallym University
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KIM Sung
Department of Pediatrics, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University
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