Effects of Ginkgo biloba Extract on Promotion of Neurogenesis in the Hippocampal Dentate Gyrus in C57BL/6 Mice
スポンサーリンク
概要
- 論文の詳細を見る
Ginkgo biloba leaf extract (Gb) has been known to improve blood flow and preclude the tissue from free radical damage. Effects of Gb were examined by using Ki67, a specific proliferative marker for cellular proliferation, and doublecortin (DCX), a marker for immature neurons, indicating degree of neuroblast differentiation in the hippocampal dentate gyrus (DG) of adult C57BL/6 mice. The mice were fed with Gb at 40 and 100 mg/kg once daily for 28 days. The increase of Ki67- and DCX-immunoreactive cells in the DG was increased in a dose-dependent manner. Especially, the group having 100 mg/kg Gb showed a significant increase of DCX-immunoreactive neuroblasts with well-developed tertiary dendrites. Expression of DCX protein in the Gb groups was also significantly increased upon compared with the vehicle group. The results suggested that repeated intake of Gb would enhance cell proliferation and neuroblast differentiation in the mouse DG.
著者
-
HWANG In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
-
CHOI Jung
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
-
YOO Ki-Yeon
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
-
LEE Choong
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
-
YOON Yeo
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
-
WON Moo-Ho
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
-
Kim Dong-woo
Central Research Institute Natural F&p Co. Ltd.
-
Yoo Dae
Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for V
-
Kim Yo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
-
Hwang In
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
-
Yoon Yeo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
-
Lee Choong
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
-
Choi Jung
Department Of Anatomy And Neurobiology College Of Medicine Hallym University
-
Nam Young
Department Of Anatomy College Of Veterinary Medicine And School Of Agricultural Biotechnology Seoul
-
NAM YoonYi
Institute of Natural Medicine, College of Medicine, Hallym University
-
KIM Woosuk
Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for V
-
PARK Jaeil
Central Research Center, Natural F&P Co. Ltd
-
Kim Yeong-in
Department Of Neurology Kangnam St. Mary's Hospital The Catholic University Of Korea
-
Yoo Ki-yeon
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
関連論文
- 成犬ならびに老犬の歯状回と海馬におけるグリア線維酸性蛋白免疫染色性の変化(解剖学)
- 癲癇抵抗性及び感受性スナネズミの海馬における小膠細胞及び星状膠細胞マーカータンパク質の特異的免疫反応性(解剖学)
- 一過性大脳虚血を施したスナネズミ皮質体性感覚野におけるGlutamic acid decarboxylase 67免疫反応性ならびにタンパク質レベルの一過性増加(解剖学)
- 癪癇感受性スナネズミの視床下部室旁核におけるTyrosine hydroxylaseの減少(解剖学)
- スナネズミ十二指腸の筋層間神経叢におけるカルビンジンD-28k陽性ニューロンの年齢に伴う変化(解剖学)
- Gliosis in the Amygdala Following Myocardial Infarction in the Rat
- スナネズミ海馬CA1領域におけるイオン化カルシウム結合アダプター分子1の免疫反応性及びタンパクレベルの年齢に伴う変化(解剖学)
- 種々月齢の特発性高血圧ラット歯状回におけるDoublecortin陽性神経前駆細胞 : SDラットとの比較について(解剖学)
- 成犬と老犬の海馬CA1領域における脂質過酸化反応とCu,Zn-superoxide dismutaseの違い(解剖学)
- Comparison of α-synuclein immunoreactivity and protein levels in ischemic hippocampal CA1 region between adult and aged gerbils and correlation with Cu,Zn-superoxide dismutase
- Anatomy: Effects of electroacupuncture at Zusanli and Baihui on brain-derived neurotrophic factor and cyclic AMP response element-binding protein in the hippocampal dentate gyrus
- Whole Blood and Red Blood Cell Manganese Reflected Signal Intensities of T1-Weighted Magnetic Resonance Images better than Plasma Manganese in Liver Cirrhotics
- Effects of Methimazole on the Onset of Type 2 Diabetes in Leptin Receptor-Deficient Rats(Laboratory Animal Science)
- Ge/GeO_2 Interface Control with High-Pressure Oxidation for Improving Electrical Characteristics
- Effects of Ginkgo biloba Extract on Promotion of Neurogenesis in the Hippocampal Dentate Gyrus in C57BL/6 Mice
- Fluorescent Calix[4]arene-appended Silica Nanotubes as Selective Chemosensor and Adsorbent for Pb^ Ion
- A Study of a Regeneration Reaction for Desulfurization Sorbents Using Natural Manganese Ore
- Antimutagenicity and Cytotoxicity of the Constituents from the Aerial Parts of Rumex acetosa(Pharmacognosy)
- ウサギの内臓表面で観察されたボンハン管とボンハン小体の組織学的特徴
- Perineural invasion is a prognostic factor for biochemical failure after radical prostatectomy
- Metabolite Profiling of Cheonggukjang, a Fermented Soybean Paste, Inoculated with Various Bacillus Strains during Fermentation
- Real-Time Observation of Single-Electron Movement through Silicon Single-Electron Transistor
- Age-Dependent Changes in Iron Deposition in the Gerbil Hippocampus
- ラット主嗅球におけるカルレチニン陽性傍糸球体細胞(Periglomerular cells)の生後変化(解剖学)
- Seizure-induced changes of mineralocorticoid and glucocorticoid receptors in the hippocampus in seizure sensitive gerbils
- Comparative Study on the Modulation of IgE and Cytokine Production by Phellinus linteus Grown on Germinated Brown Rice, Phellinus Linteus and Germinated Brown Rice in Murine Splenocytes
- Histological aspect of threadlike structure inside blood vessel(International Conference on Mind Body Science : Physical and Physiological Approach joint with The Eighteenth Symposium on Life Information Science)
- Comparison of Density and Morphology of Neuroblasts in the Dentate Gyrus among Variously Aged Dogs, German Shepherds(Anatomy)
- Reduction of Calbindin D-28k-Immunoreactive Neurons in the Dog Dentate Gyrus
- Differential effects and changes of ceruloplasmin in the hippocampal CA1 region between adult and aged gerbils after transient cerebral ischemia
- Berberry Extract Reduces Neuronal Damage and N-Methyl-D-aspartate Receptor 1 Immunoreactivity in the Gerbil Hippocampus after Transient Forebrain Ischemia(Molecular and Cell Biology)
- Mineralocorticoid and glucocorticoid receptor expressions in astrocytes and microglia in the gerbil hippocampal CA1 region after ischemic insult
- Elevated voltage gated Cl^- channel expression enhances fast paired-pulse inhibition in the dentate gyrus of seizure sensitive gerbil
- Up-regulation of P/Q-type voltage-gated Ca^ channel immunoreactivity within parvalbumin positive neurons in the rat hippocampus following status epilepticus
- The effect of topiramate on GABA_B receptor, vesicular GABA transporter and paired-pulse inhibition in the gerbil hippocampus
- Digital Logic Implementation of Wide-Range Frequency Linear Detector
- GC-MS Based Metabolite Profiling of Rice Koji Fermentation by Various Fungi
- Changes in Na^+-K^+-Cl^- cotransporter immunoreactivity in the gerbil hippocampus following transient ischemia
- Nutrient Effects of FK-506,a New Immunosuppressant, Production by Streptomyces sp. in a Defined Medium
- Ischemia-Related Changes in Galanin Expression in the Dentate Hilar Region after Transient Forebrain Ischemia in Gerbils
- Altered GABA_B receptor immunoreactivity in the gerbil hippocampus induced by baclofen and phaclofen, not seizure activity
- 肥満型及び痩せ型Zucker糖尿病肥満ラットの視床下部におけるオレキシンA及びニューロペプタイドYの発現変化(解剖学)
- Expressional Changes of Neuropeptide Y and Cholecystokinin in the Arcuate and Paraventricular Nuclei after Capsaicin Administration
- 高脂肪飼料飼育ラットの脳におけるコレクトキニンとニューロペプチド発現に関するカプサイシンの効果(解剖学)
- Improvement of Fuzzy ARTMAP Performance in Noisy Input Environment Using Weighted-Average Learning
- Effect of Dietary Level of Pectin on Immunoglobulin and Cytokine Production by Mesenteric Lymph Node Lymphocytes and Interleukin-2 Receptor in Rats
- Efficacy of Dietary Aloe vera Supplementation on Hepatic Cholesterol and Oxidative Status in Aged Rats
- Effects of Electroacupuncture at Zusanli and Baihui on Brain-Derived Neurotrophic Factor and Cyclic AMP Response Element-Binding Protein in the Hippocampal Dentate Gyrus
- Species-Difference of Cyclooxygenase-2 in the Hippocampus of Rodents
- Effects of High Cholesterol Diet on Newly Generated Cells in the Dentate Gyrus of C57BL/6N and C3H/HeN Mice
- Immunohistochemical Changes in Orexigenic and Anorexigenic Neuropeptides in the Rat Hypothalamus after Capsaicin Administration
- Ribosomal Protein S3 Immunoreactivity in the Young, Adult and Aged Gerbil Hippocampus
- Anatomy: Ribosomal Protein S3 Immunoreactivity in the Young, Adult and Aged Gerbil Hippocampus
- Differential Effects of Treadmill Exercise on Calretinin Immunoreactivity in Type 2 Diabetic Rats in Early and Chronic Diabetic Stages
- Effects of S-Allyl-L-Cysteine on Cell Proliferation and Neuroblast Differentiation in the Mouse Dentate Gyrus
- A Correlation between Antioxidant Activity and Metabolite Release during the Blanching of Chrysanthemum coronarium L.
- Inhibitory Effects of Calycosin Isolated from the Root of Astragalus membranaceus on Melanin Biosynthesis(Pharmacognosy)
- Mucinous Eccrine Nevus
- Acute Generalized Exanthematous Pustulosis in a Six-Year-Old Boy
- Case of congenital esophageal stricture by ganglioneuroma and acro-flexural hyperpigmentation : A coincidence?
- Neuronal Degeneration and Microglial Activation in the Ischemic Dentate Gyrus of the Gerbil
- Risk factors for the different types of chronic lung diseases of prematurity according to the preceding respiratory distress syndrome
- Clinical characteristics of chronic lung disease without preceding respiratory distress syndrome in preterm infants
- A Method for Studying the Electric Field Enhanced Emission of Carriers from Deep Levels
- Narrow-band Stokes Wave Generation and Amplification in a Pulsed Fiber Raman Laser Using a Double-pass Scheme
- Effect of Dietary Pectin on the Production of Immunoglobulins and Cytokines by Mesenteric Lymph Node Lymphocytes in Mouse Colitis Induced with Dextran Sulfate Sodium(Food & Nutrition Science)
- Electrochemical Detection of Triacylglycerol Hydroperoxides by Reversed Phase High-performance Liquid Chromatography
- Correlation between Antioxidative Activities and Metabolite Changes during Cheonggukjang Fermentation
- Cystadenoma of the seminal vesicle
- IS-74 A clinical study of depression symptoms during pregnancy(Group9 Perinatology2,International Session)
- Cytopathology of Cervical Cancer in Korea
- Recovery from tanning induced by narrow-band UVB phototherapy in brown-skinned individuals with psoriasis : Twelve-month follow-up
- Junctionless Ge p-Channel Metal--Oxide--Semiconductor Field-Effect Transistors Fabricated on Ultrathin Ge-on-Insulator Substrate
- N-Acetylserotonin Increases Cell Proliferation and Differentiating Neuroblasts with Tertiary Dendrites through Upregulation of Brain-Derived Neurotrophic Factor in the Mouse Dentate Gyrus
- Metabolite Profiling of Cheonggukjang, a Fermented Soybean Paste, Inoculated with Various Bacillus Strains during Fermentation
- Calcinosis cutis of the fingertip associated with Raynaud's phenomenon
- Eruptive pseudoangiomatosis
- Plasma Cell Cheilitis Treated with Intralesional Injection of Corticosteroids
- Effect of Pulse Frequency on Corrosion Behavior of AZ91 Mg Alloy Treated by Microarc Discharge Oxidation Coating
- Correlation between Antioxidative Activities and Metabolite Changes during Cheonggukjang Fermentation
- A Correlation between Antioxidant Activity and Metabolite Release during the Blanching of Chrysanthemum coronarium L.
- GC-MS Based Metabolite Profiling of Rice Koji Fermentation by Various Fungi
- High-Electron-Mobility Ge n-Channel Metal-Oxide-Semiconductor Field-Effect Transistors with High-Pressure Oxidized Y_2O_3
- Epidemiological characteristics of genital herpes and condyloma acuminata in patients presenting to urologic and gynecologic clinics in Korea
- Do Escherichia coli extract and cranberry exert preventive effects on chronic bacterial prostatitis? Pilot study using an animal model
- EM2-3: Experimental and Numerical Investigation on the Urea SCR Dosing System to Improve NO_x Reduction Efficiency(EM: Exhaust Emission Control and Measurement,General Session Papers)
- Variation of Surface Roughness on Ge Substrate by Cleaning in Deionized Water and its Influence on Electrical Properties in Ge MetalOxideSemiconductor Field-Effect Transistors
- Generation of reduced macrolide analogs by regio-specific biotransformation
- Tubular anomalous bones found in both thighs of a long-tailed macaque (Macaca fascicularis)
- Prevalence of sexually transmitted infections and sexual behavior of young adults and middle-aged people presenting to health examination centers in Korea
- Comparing the Effects of Acupuncture and Electroacupuncture at Zusanli and Baihui on Cell Proliferation and Neuroblast Differentiation in the Rat Hippocampus
- Changes in Cyclooxygenase-2 Immunoreactivity in the Hippocampus in a Model of Streptozotocin-Induced Type 1 Diabetic Rats
- Metabolomics-Based Optimal Koji Fermentation for Tyrosinase Inhibition Supplemented with Astragalus Radix
- Experimental and Analytical Characterization of Dual-Gated Germanium Junctionless p-Channel Metal--Oxide--Semiconductor Field-Effect Transistors
- Biosynthesis of rapamycin and its regulation : past achievements and recent progress
- 癲癇抵抗性及び感受性スナネズミの海馬における小膠細胞及び星状膠細胞マーカータンパク質の特異的免疫反応性
- Oxidation Rate Reduction of Ge with O_2 Pressure Increase
- Simultaneous Bilateral Stenosis of the Vertebral Arteries Treated by Unilateral Decompression: A Case Report
- Step and Terrace Formation on Ge(111) Surface in H_2 Annealing
- Impact of diabetes mellitus on recurrence and progression in patients with non-muscle invasive bladder carcinoma : A retrospective cohort study