Antimutagenicity and Cytotoxicity of the Constituents from the Aerial Parts of Rumex acetosa(Pharmacognosy)
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概要
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Four anthraquinones isolated for the first time from the aerial parts of Rumex acetosa (Polygonaceae), a Korean and a Japanese medicinal plant, and two synthetic derivatives were examined for their cytotoxicities against five cultured human tumor cell lines, i.e. A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCY15 (colon), using the Sulfrhodamine-B method in vitro and antimutagenic activities by Ames test with Salmonella typhimurium TA98 and TA100 and SOS chromotest with E. coli PQ37. Among the tested compounds, emodin strongly inhibited the proliferation of each examined tumor cell line with IC_<50> values ranged from 2.94 to 3.64μg/ml and showed potent antimutagenic activities with 71.5% and 53.3% at the concentration of 0.1mg/plate against the mutagens, NPD and sodium azide, respectively. Its antigenotoxic activity was also very effective at the final concentration of 10μg/reaction tube against the mutagens, MNNG and NQO by SOS chromotest, reducing the induction factors by 19.6% and 43.5%, respectively. The structure-activity correlation study suggests that an additional OH group at C-6 position in the anthraquinone nucleus may play an important role for their cytotoxicities and an introduction of OH- or OCH, group at C-6 position is necessary for their antimutagenicities.
- 2005-11-01
著者
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LEE Nam
Department of Chemistry, Korea Military Academy
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CHOI Jung
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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Lee Dong
Department Of Environmental Atmospheric Science Pukyong National University
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Choi Jung-hyun
Dep. Of Biotechnology Dongguk Univ.
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Choi Jung
Department Of Anatomy And Neurobiology College Of Medicine Hallym University
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Ryu Shi-yong
Korea Res. Inst. Of Chemical Technol.
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Lee Nam
Department Of Biochemistry Dongguk University
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Lee Seung
School Of Life And Health Sorabol College
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KOO Byung
Department of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University
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RYU Shi
Korea Research Institute of Chemical Technology
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HAN Yeong
Department of Biology, Dongguk University
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LEE Seung
Sorabol College
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KOO Byung-Soo
Department of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University
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LEE Nam-Jae
Department of Biochemistry, Dongguk University
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Koo Byung
Department Of Oriental Neuropsychiatry College Of Oriental Medicine Dongguk University
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Lee Dong
Department Of Biotechnology College Of Natural Science Dongguk University
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Han Yeong
Department Of Biology Dongguk University
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Koo B‐s
Dongguk Univ. Seoul Kor
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Lee Dong-ung
Dep. Of Biotechnology Dongguk Univ.
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Han Yeong-hwan
Department Of Biology Dongguk University
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Choi Jung-hyun
Department Of Biotechnology Dongguk University
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Lee Dong
Department Of Aerospace Engineering Chonbuk National University
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Choi Jung
Department Of Agricultural Biotechnology Seoul National University
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Koo Byung-Soo
Department of Neuropsychiatry, Graduate School of Oriental Medicine, Dongguk University
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