Protective Effect of Triphlorethol-A from Ecklonia cava against Ionizing Radiation in vitro

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概要

• 論文の詳細を見る

• We studied the cytoprotective effect of triphlorethol-A against γ-ray radiation-induced oxidative stress. In this study, hydrogen peroxide, which is a reactive oxygen species (ROS), was detected using 2',7'-dichlorodihydrofluorescein diacetate (DCF-DA) assay. Triphlorethol-A reduced intracellular hydrogen peroxide generated by γ-ray radiation. This compound provided protection against radiation-induced membrane lipid peroxidation and cellular DNA damage which are the main targets of radiation-induced damage. Triphlorethol-A protected the cell viability damaged by the radiation through inhibition of apoptosis. Triphlorethol-A reduced the expression of bax and activated caspase 3 induced by radiation, but recovered the expression of bcl-2 decreased by radiation. Taken together, the results suggest that triphlorethol-A protects cells against oxidative damage induced by radiation through reducing ROS.

• 日本放射線影響学会の論文
• 2006-03-31

著者

• LEE Nam

  Department of Chemistry, Korea Military Academy

• ZHANG Rui

  Department of Cardiology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine

• Lee Nam

  Dep. Of Chemistry Coll. Of Natural Sciences Cheju National Univ.

• Lee Nam

  Department Of Chemistry College Of Natural Sciences Cheju National University

• KWAK Young

  Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine

• Park Jae

  Department of Nuclear and Energy Engineering, Jeju National University

• Kim Bum

  Department Of Microbiology And Cancer Research Institute Seoul National University College Of Medici

• Kim Bum

  Department Of Chemical Engineering Sungkyunkwan University

• Lee Kyoung

  Department Of Biochemistry College Of Medicine And Applied Radiological Science Research Institute C

• Kwak Young

  Department Of Anesthesiology And Pain Medicine Yonsei University College Of Medicine

• Lee Nam

  Department Of Biochemistry Dongguk University

• Kang Kyoung

  School Of Medicine And Applied Radiological Science Research Institute Cheju National University

• KANG Kyoung

  Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute,

• HYUN Jin

  Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute,

• CHAE Sungwook

  Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute,

• Hyun Jin

  School Of Medicine And Applied Radiological Science Research Institute Cheju National University

• Park Jae

  Department Of Nuclear And Energy Engineering Cheju National University

• Park Jae

  Department Of Applied Bioscience And Biotechnology Faculty Of Life And Environmental Science

• Chae Sungwook

  Department Of Biochemistry College Of Medicine And Applied Radiological Science Research Institute C

• Zhang Rui

  School Of Medicine And Applied Radiological Science Research Institute Cheju National University

• Zhang Rui

  Department Of Cardiology Rui Jin Hospital Shanghai Jiao Tong University School Of Medicine

• Chae S

  Department Of Biochemistry College Of Medicine And Applied Radiological Science Research Institute C

• Hyun Jin

  Department Of Biochemistry College Of Medicine Cheju National University

• Zhang Rui

  Department Of Biology The Pennsylvania State University

• Zhang Rui

  Department Of Biochemistry And Molecular Biology Fourth Military Medical University

• Kwak Young

  Department Of Anesthesiology And Pain Medicine Anesthesia And Pain Research Institute Yonsei University College Of Medicine

• Park Jae

  Department of Advanced Materials Science and Engineering, Sungkyunkwan University, Suwon, Kyunggi-do 440-746, South Korea

• KOH Young

  Department of Psychiatry, College of Medicine, Cheju National University

• KANG Kyoung

  College of Medicine, Jeju National University

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