Phloroglucinol Exerts Protective Effects Against Oxidative Stress–Induced Cell Damage in SH-SY5Y Cells
スポンサーリンク
概要
- 論文の詳細を見る
In this study, we explored whether phloroglucinol (1,3,5-trihydroxybenzene) exerts protective effects against oxidative stress–induced cytotoxicity in SH-SY5Y cells, a neuroblastoma cell line. The central nervous system is especially vulnerable to oxidative stress because the brain consumes large amounts of energy to perform its complicated functions, but contains a lower level of anti-oxidant enzymes compared with other peripheral tissues. In SH-SY5Y cultures, pretreatment with 10 <I>μ</I>g/ml of phloroglucinol attenuates the cytotoxicity of hydrogen peroxide. In addition, when assessed with 2′,7′-dichlorofluorescein diacetate dye, the increase in reactive oxygen species (ROS) induced by hydrogen peroxide was significantly reduced by pretreatment with phloroglucinol. ROS is known to cause lipid peroxidation of the cell membranes, the carbonylation of intracellular proteins, and DNA damage, which can lead to various cellular dysfunctions and eventually cellular death. We found that pretreatment with phloroglucinol down-regulated the levels of 8-isoprostane, protein carbonylation, and 8-hydroxy deoxyguanine caused by hydrogen peroxide treatment in SH-SY5Y cells. These results indicate that phloroglucinol exerts protective effects against oxidative stress-induced cell damage in SH-SY5Y cells.
著者
-
Lee Kyoung
Department Of Biochemistry College Of Medicine And Applied Radiological Science Research Institute C
-
Lee Nam
Department Of Biochemistry Dongguk University
-
Kim Hee
School Of Materials Science And Engineering Seoul National University
-
Kang Kyoung
College Of Medicine Jeju National University
-
Hyun Jin
College Of Medicine Jeju National University
-
Kim Hye-sun
Department Of Pharmacology And Biomedical Sciences Seoul National University College Of Medicine
-
LEE Kihwan
Department of Pharmacology and Biomedical Sciences, Seoul National University College of Medicine
関連論文
- Actinomycin D Identified as an Inhibitor of Discoidin Domain Receptor 2 Interaction with Collagen through an Insect Cell Based Screening of a Drug Compound Library(Pharmacology)
- 1,2,3,4,6-Penta-O-galloyl-β-D-glucose Protects Splenocytes against Radiation-Induced Apoptosis in Murine Splenocytes
- Isolation and characterization of a novel analyte from Bacillus subtilis SC-8 antagonistic to Bacillus cereus(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Electrical characterization of indium-rich InGaN/GaN multi quantum wells (Electron devices: 第15回先端半導体デバイスの基礎と応用に関するアジア・太平洋ワークショップ(AWAD2007))
- Electrical characterization of indium-rich InGaN/GaN multi quantum wells (Silicon devices and materials: 第15回先端半導体デバイスの基礎と応用に関するアジア・太平洋ワークショップ(AWAD2007))
- Antimutagenicity and Cytotoxicity of the Constituents from the Aerial Parts of Rumex acetosa(Pharmacognosy)
- Cytoprotective Effects of KIOM-79 on Streptozotocin Induced Cell Damage by Inhibiting ERK and AP-1(Highlighted paper selected by Editor-in-chief,Biochemistry)
- Caffeic Acid Protects Hydrogen Peroxide Induced Cell Damage in WI-38 Human Lung Fibroblast Cells(Molecular and Cell Biology)
- Protective Effect of Triphlorethol-A from Ecklonia cava against Ionizing Radiation in vitro
- Cytotoxic Effect of 7β-Hydroxycholesterol on Human NCI-H460 Lung Cancer Cells(Molecular and Cell Biology)
- Effect of Physical Exercise on Renal Response to Head-Out Water Immersion
- IS-020 Prenatal Diagnostic Clues for Fetus-in-fetu(the 44th Annual Meeting of Japanese Society of Pediatric Surgeons)
- Antimutagenic Activity of 5α-Cholest-7-en-3β-ol, a New Component from the Starfish Asterina pectinifera
- Characterization of Lactobacillus spp. isolated from the feces of breast-feeding piglets(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Effect of Palmitoleic Acid on Melanogenic Protein Expression in Murine B16 Melanoma
- A Case of Pre-Sezary Syndrome Preceded by Hand Lesions
- The effect of stabilizing layer on the SNR and thermal stability in the strongly coupled AFC media by micromagnetics simulation (マルチメディアストレージ 第6回アジア情報記録技術シンポジウム〔英文〕)
- The effect of stbilizing layer on the SNR and thermal stability in the strongly coupled AFC media by micromagnetics simulation
- Poisson Equations with Nonlinear Source Terms on Networks
- Depigmentation of Melanocytes by (2Z,8Z)-Matricaria Acid Methyl Ester Isolated from Erigeron breviscapus
- Tepidimonas arfidensis Sp. Nov., a Novel Gram-Negative and Thermophilic Bacterium Isolated from the Bone Marrow of a Patient with Leukemia in Korea
- Bayesian Approach to Optimal Release Policy of Software System(Reliability, Maintainability and Safety Analysis)
- Chemical Composition and Anti-inflammatory Effects of Essential Oil from Farfugium japonicum Flower
- A RELATION ON SUBTRACTION ALGEBRAS
- Sasa quelpaertensis Phenylpropanoid Derivative Suppresses Lipopolysaccharide-induced Nitric Oxide Synthase and Cyclo-oxygenase-2 Expressions in RAW 264.7 Cells
- Biological Activities of Korean Citrus obovoides and Citrus natsudaidai Essential Oils against Acne-Inducing Bacteria
- Optimal Trajectory for the Atlantooccipital Transarticular Screw
- THE ESSENCE OF SUBTRACTION ALGEBRAS
- Electrical Properties of Self-Assembled Monolayers Using STM
- Prenatal diagnostic clue for fetus in fetu
- Residual anterior chamber angle closure in narrow-angle eyes following laser peripheral iridotomy : anterior segment optical coherence tomography quantitative study
- Whole-Blood Interferon-Gamma Release Assay for Diagnosis of Tuberculous Lymphadenitis
- Narrow antagonistic activity of antimicrobial peptide from Bacillus subtilis SCK-2 against Bacillus cereus(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Mycobacterium abscessus Pulmonary Infection Presenting as a Solitary Pulmonary Nodule
- Process Optimization for Synthesis of High-Quality Graphene Films by Low-Pressure Chemical Vapor Deposition (Special Issue : Microprocesses and Nanotechnology)
- Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on Changes in Postural Balance and Muscle Contraction following Muscle Fatigue
- Acute meningitis as an initial manifestation of Erysipelothrix rhusiopathiae endocarditis
- Soft X-ray Microscope Constructed with 130-nm Spatial Resolution Using a High Harmonic X-ray Source
- Early versus delayed laparoscopic cholecystectomy after percutaneous transhepatic gallbladder drainage
- Direct-Puncture Embolization of Scalp Arteriovenous Fistulae : Technical Note on the Circular Compression Device
- Phloroglucinol Exerts Protective Effects Against Oxidative Stress-Induced Cell Damage in SH-SY5Y Cells
- Effects of Rhythmic Auditory Stimulation (RAS) on Gait Ability and Symmetry after Stroke
- Phloroglucinol Exerts Protective Effects Against Oxidative Stress–Induced Cell Damage in SH-SY5Y Cells
- Eckol Inhibits Ultraviolet B-Induced Cell Damage in Human Keratinocytes via a Decrease in Oxidative Stress
- Actinomycin D Identified as an Inhibitor of Discoidin Domain Receptor 2 Interaction with Collagen through an Insect Cell Based Screening of a Drug Compound Library
- Virtual-Reality Balance Training with a Video-Game System Improves Dynamic Balance in Chronic Stroke Patients
- Biosystematic Studies on the Family Tofieldiaceae IV. Taxonomy of Tofieldia coccinea in Japan and Korea Including a New Variety
- The Effect of Biofeedback-based Balance Training while Performing Cognitive Tasks on Temporal and Spatial Parameters and Gait Stability of the Elderly
- Photoprotective effect of Undaria crenata against ultraviolet B-induced damage to keratinocytes(MISCELLANEOUS)
- Generation of high-producing cell lines by overexpression of cell division cycle 25 homolog A in Chinese hamster ovary cells(CELL AND TISSUE ENGINEERING)
- Electrostatic Force Microscopy of Metallic Ion-Intercalated DNA
- Measurements of Surgeons' Exposure to Ionizing Radiation Dose During Intraoperative Use of C-Arm Fluoroscopy