Eckol Inhibits Ultraviolet B-Induced Cell Damage in Human Keratinocytes via a Decrease in Oxidative Stress
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概要
- 論文の詳細を見る
In previous reports, the antioxidant effects of eckol were shown to protect cells against hydrogen peroxide- and gamma ray-induced oxidative stress. In this study, the role of eckol in protecting human skin keratinocytes (HaCaT) against UVB-induced oxidative cell damage was investigated. Also, triphlorethol-A, one of the chemical components in Ecklonia cava, and quercetin a well known antioxidant, were compared with eckol in terms of antioxidant activity based on chemical structure. Eckol decreased UVB-induced intracellular reactive oxygen species (ROS), decreased injury to cellular components resulting from UVB-induced oxidative stress, and restored cell viability. In addition, eckol reduced UVB-induced apoptosis by inhibiting the disruption of mitochondrial membranes. These results suggest that eckol protects human keratinocytes against UVB-induced oxidative stress by scavenging ROS, thereby lessening injury to cellular components.
- 公益社団法人 日本薬学会の論文
著者
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Lee Nam
Department Of Biochemistry Dongguk University
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PIAO Mei
School of Medicine and Applied Radiological Science Research Institute, Cheju National University
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Hyun Jin
School Of Medicine And Applied Radiological Sci. Res. Inst. Jeju National Univ.
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Chae Sungwook
Aging Research Center Korea Institute Of Oriental Medicine
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Piao Mei
School of Medicine and Veterinary Medical Research Institute, Jeju National University
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Hyun Jin
School of Medicine and Veterinary Medical Research Institute, Jeju National University
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