Preventive Effect of 7,8-Dihydroxyflavone against Oxidative Stress Induced Genotoxicity(Biochemistry)
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概要
- 論文の詳細を見る
We elucidated the protective effect of 7,8-dihydroxyflavone against hydrogen peroxide (H_2O_2)-induced DNA damage. We found that 7,8-dihydroxyflavone scavenges 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and intracellular reactive oxygen species (ROS). 7,8-Dihydroxyflavone with antioxidant effect prevented the H_2O_2-induced cellular DNA damage, as evidenced by comet tail, 8-hydroxy-2'-deoxyguanosine (8-OHdG) content, and phospho-histone H2A. X protein expression. Hence, 7,8-dihydroxyflavone was shown to protect cell via the inhibition of apoptosis induced by H_2O_2. This was substantiated by decreased apoptotic nuclear fragmentation, decreased sub-G_1 cell population, and decreased DNA fragmentation. Furthermore, 7,8-dihydroxyflavone activated the protein kinase B (PKB, Akt) signal pathway, which is a major survival signal pathway. In addition, LY294002, which is phosphatidylinositol 3 kinase (PI3K, upstream of Akt) inhibitor, attenuated the protective effect of 7,8-dihydroxyflavone against H_2O_2-induced cell damage. In conclusion, 7,8-dihydroxyflavone was shown to possess cytoprotective properties against oxidative stress by scavenging intracellular ROS and enhancing Akt activity.
- 社団法人日本薬学会の論文
- 2009-02-01
著者
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LEE In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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KANG Sam
Natural Products Institute, Seoul National University
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Kang Sam
韓国
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Kang Sam
Natural Products Research Institute And College Of Pharmacy Seoul National University
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Kim Bum
Department Of Microbiology And Cancer Research Institute Seoul National University College Of Medici
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ZHANG Rui
School of Pharmaceutical Sciences, Peking University
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Kim Bum
Department Of Chemical Engineering Sungkyunkwan University
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Kang Sam
Natural Product Research Institute Seoul National University
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Kang Kyoung
School Of Medicine And Applied Radiological Science Research Institute Cheju National University
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PIAO Mei
School of Medicine and Applied Radiological Science Research Institute, Cheju National University
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KO Dong
School of Medicine and Applied Radiological Science Research Institute, Cheju National University
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WANG Zhi
School of Medicine and Applied Radiological Science Research Institute, Cheju National University
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CHANG Weon
School of Medicine and Applied Radiological Science Research Institute, Cheju National University
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YOU Ho
Dppartment of Pharmacology, College of Medicine, Chosun University
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HYUN Jin
School of Medicine and Applied Radiological Science Research Institute, Cheju National University
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Hyun Jin
School Of Medicine And Applied Radiological Science Research Institute Cheju National University
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You Ho
Dppartment Of Pharmacology College Of Medicine Chosun University
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Kang S
Natural Products Research Institute And College Of Pharmacy Seoul National University
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Ko Dong
School Of Medicine And Applied Radiological Science Research Institute Cheju National University
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Piao Meijing
School Of Medicine And Applied Radiological Science Research Institute Cheju National University
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Zhang Rui
School Of Medicine And Applied Radiological Science Research Institute Cheju National University
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Chang Weon
School Of Medicine And Applied Radiological Science Research Institute Cheju National University
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Wang Zhi
School Of Medicine And Applied Radiological Science Research Institute Cheju National University
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Lee In
Department Of Agronomy College Of Agriculture And Life Sciences Kyungpook National University
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Lee In
Department Of Microbiology And Cancer Research Institute Seoul National University College Of Medici
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Lee In
Department Of Aerospace Engineering
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Hyun Jin
School Of Medicine And Applied Radiological Sci. Res. Inst. Jeju National Univ.
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Kang Kyoung
School Of Medicine And Applied Radiological Sci. Res. Inst. Jeju National Univ.
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Zhang Rui
School Of Medicine And Applied Radiological Sci. Res. Inst. Jeju National Univ.
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KANG Kyoung
College of Medicine, Jeju National University
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KANG Kyoung
School of Mechanical Engineering, Yonsei University
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