Flavonols Inhibit Sortases and Sortase-Mediated Staphylococcus aureus Clumping to Fibrinogen(Pharmacology)
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概要
- 論文の詳細を見る
Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. In Staphylococcus aureus, deletion of the sortase isoforms results in marked reduction in virulence and infection potential, making it an important antivirulence target. We examined the effects of naturally occurring flavonols on recombinant sortase A (SrtA) and B (SrtB) prepared from S. aureus ATCC6538p and found that these compounds inhibited the activity of sortases, without exhibiting antibacterial activities. Among the flavonols tested, morin, myricetin, and quercetin exhibited strong sortase inhibitory activities (SrtA IC_<50>: 37.39-52.70μM, SrtB IC_<50>:8.54-36.89μM). The fibrinogen cell-clumping activity data highlight the potential of flavonols for the treatment of S. aureus infections via inhibition of sortase.
- 社団法人日本薬学会の論文
- 2006-08-01
著者
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KANG Sam
Natural Products Institute, Seoul National University
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Kim Ji-yun
Natural Products Research Institute College Of Pharmacy Seoul National University
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Kang Sam
Natural Product Research Institute Seoul National University
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Oh Ki-bong
School Of Agricultural Biotechnology Seoul National University
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Oh Ki-bong
Seoul National University School Of Agricultural Biotechnology:center For Agricultural Biomaterials
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KIM Jae-Gyu
School of Agricultural Biotechnology, Seoul National University
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LEE Tae-Hoon
School of Agricultural Biotechnology, Seoul National University
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LEE Tae-Hoon
Seoul National University, School of Agricultural Biotechnology
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Lee Tae-hoon
Seoul National University School Of Agricultural Biotechnology
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Oh Ki-bong
School Of Agricultural Biotechnology Seoul National Univ.
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